ABSTRACT
Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independent of adiposity. The purpose of this study was to investigate the effects of a single session of combined exercise on leptin levels and insulin resistance index in sedentary men. Ten male subjects [22.9 +/- 1.7 years] and BMI [23 +/- 1.7kg.m[-2]] performed a single session of combined exercise including aerobic exercise: 60-70% of their maximal oxygen consumption for 20 min, and resistance exercise: 2 sets of 10 repetitions at 70% of 1 repetition in maximum. Leptin, glucose, insulin and insulin resistance indexes were measured before and 24 h after an exercise. There were significant differences for leptin [ng.ml[-1]] [pre, 4.97[1.44]; post, 3.84[0.83]], and insulin resistance index [pre, 1.25[0.33]; post, 1.02[0.16]] [p<0.05]. But glucose [mmol.l[-1]] [pre, 4.4[0.42]; post, 4.25[0.4]], and insulin concentration [micro U.ml[-1] micro .ml[-1]] [pre, 5.8[0.74]; post, 5.39[0.48]] had significantly no changes after 24 h post-exercise. This study has suggested a single session of combined exercise along with a significant change of the leptin levels can affect positively on insulin resistance index